| Reciprocal regulation of mesenchymal stem cells and immune responses |
| 论文作者 |
Wang, Y; Fang, JK; Liu, BM; Shao, CS; Shi, YF |
| 期刊/会议名称 |
CELL STEM CELL |
| 论文年度 |
2022 |
| 论文类别 |
Review |
| 摘要 |
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for autoimmune diseases, organ fail-ures, and many other chronic disorders. Remarkably, the reparative and homeostatic maintenance functions of MSCs rely on their interaction with the inflammatory microenvironment. Here, we discuss the characteris-tics and functions of MSCs under different pathophysiological conditions and highlight how the immunomod-ulatory functions of MSCs are altered in accordance with the inflammatory cues. We hope to provide new insights into the diverse immunoregulatory properties of MSCs during tissue regeneration and therapy. |
| 期 |
11 |
| 卷 |
29 |
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